Food Tastes “Weird” on Ozempic — Experts Are Starting to Understand Why

Many people taking Ozempic and similar weight-loss drugs are noticing something unusual: food doesn’t taste the same anymore. Some say they’ve lost interest in meat, fried foods, and even long-time favorites. Now, scientists are starting to understand what’s going on.

GLP-1 drugs like Ozempic, Wegovy, and Zepbound were first made to treat diabetes by helping the body release insulin. They also help people feel full faster, leading to weight loss. But users are now reporting deeper changes — like disliking certain flavors, tasting strange aftertastes, or even losing their love for food altogether.

Studies show that people on GLP-1 drugs are eating fewer processed foods, fried meals, and sweet drinks. Many are also eating more fruits and vegetables. Some say they’ve cut out as much as 700 calories a day. Scientists believe this is part of why the drugs are so effective.

Experts think two things may be happening. First, because the drugs make people feel full quickly, high-fat or heavy meals become less appealing. Second, GLP-1 drugs may be affecting how people actually taste food. Some say flavors feel too strong, bitter, or strange — like wine tasting like vegetables or curry becoming too bitter.

Scientists have found GLP-1 receptors in taste buds and in the brain’s reward system. That means the drugs might reduce the pleasure people feel from eating, or change the way their taste buds respond. However, studies on this are still small, and the results are mixed. Some show stronger taste perception, while others suggest weaker senses for all five basic tastes.

While some users welcome this change because it helps them eat less, others are struggling. One former food reporter says she no longer enjoys cooking. Another person said even favorite meals are now unappetizing.

Researchers agree that more studies are needed to fully understand how GLP-1 drugs change food taste and preferences. But for many, the health benefits seem to outweigh the loss of food enjoyment — at least for now.